Article

Lyophilized <i>B. subtilis</i> ZB183 Spores: 90-Day Repeat Dose Oral (Gavage) Toxicity Study In Wistar Rats

2019-08-05

Abstract excerpt

A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on lyophilized spores of the novel genetically modified strain B. subtilis ZB183. Lyophilized spores at doses of 10 9 , 10 10 , and 10 11 CFU/kg body weight/day were administered by oral gavage to Wistar rats for a period of 90 consecutive days. B.Subtilis ZB183 had no effects on clinical signs, mortality,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1245bdb8-3959-5a4c-a0be-79c2033faf2d
DOI: 10.1101/724542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lyophilized <i>B. subtilis</i> ZB183 Spores: 90-Day Repeat Dose Oral (Gavage) Toxicity Study In Wistar RatsDOI 10.1101/724542Read

Safety evaluation of vitamin K2 (menaquinone-7) via toxicological tests.Semantic proximity Read

Gut delivery of pentameric GLP-1 using genetically engineered <i>Bacillus subtilis</i>Semantic proximity Read

Recurrent Septicemia in an Immunocompromised Patient Due to Probiotic Strains of <b> <i>Bacillus subtilis</i> </b>Semantic proximity Read

Comprehensive Genotoxicity and Subchronic Oral Toxicity Evaluation of Kumamolisin from Bacillus sp. MN-32 for Human UseSemantic proximity Read

Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humansSemantic proximity Read

Safety evaluation of subchronic feeding of nisI transformed Lactobacillus plantarum in Sprague‐Dawley ratsSemantic proximity Read

Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames' bacterial reverse mutation, and in vivo micronucleus assays.Semantic proximity Read

[Safety Evaluation of Rare Sugar Syrup: Single-dose Oral Toxicity in Rats, Reverse Mutation Assay, Chromosome Aberration Assay, and Acute Non-Effect Level for Diarrhea of a Single Dose in Humans].Semantic proximity Read

An evaluation of genotoxicity and 90-day repeated-dose toxicity in rats of a <i>Dracocephalum moldavica</i> powdered extractSemantic proximity Read

Immunotoxicological evaluation of corn genetically modified with Bacillus thuringiensis Cry1Ah gene by a 30-day feeding study in BALB/c mice.Semantic proximity Read

Toxicology studies with N-acetylglycine.Semantic proximity Read

Preclinical Safety Evaluation of Human Lactoferrin Alpha (Effera <sup>®</sup> )Semantic proximity Read