Article

Comprehensive Genotoxicity and Subchronic Oral Toxicity Evaluation of Kumamolisin from Bacillus sp. MN-32 for Human Use

2025-12-25

Abstract excerpt

Kumamolisin from Bacillus sp. MN-32 (produced by E. coli B/BL21 background) is an acid-active sedolisin protease developed for food uses; its systemic safety was assessed using GLP (Good-laboratory-practice) in vitro genotoxicity assays and repeated-dose oral studies. A bacterial reverse-mutation assay (OECD TG 471; Salmonella TA98, TA100, TA102, TA1535, TA1537; plate-incorporation and preincubation; ±S9) showed...

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Literature Corpus work: 75f2f45e-2f3f-5d52-84f5-4fdb81da8e47
DOI: 10.64898/2025.12.25.696157

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