Article
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131.
Scientific reports - 24 Jul 2020
Maes Mailis, Dyson Zoe A, Smith Sarah E, Goulding David A, Ludden Catherine, Baker Stephen, Kellam Paul, Reece Stephen T, Dougan Gordon, Bartholdson Scott Josefin
Abstract excerpt
The increase of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options for AMR pathogens increasingly attractive. Recent studies have demonstrated anti-bacterial efficacy of a humanised monoclonal antibody (mAb) targeting the O25b O-antigen of Escherichia coli ST131. To evaluate the phenotypic effects of antibody binding to diverse clinical E....
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