Article

Ribosome Phenotypes Enable Rapid Antibiotic Susceptibility Testing in <i>Escherichia coli</i>

2024-06-20

Abstract excerpt

Rapid antibiotic susceptibility tests (ASTs) are an increasingly important part of clinical care as antimicrobial resistance (AMR) becomes more common in bacterial infections. Here, we use the spatial distribution of fluorescently labelled ribosomes to detect intracellular changes associated with antibiotic susceptibility in single E. coli cells using a convolutional neural network (CNN). By using ribosome-target...

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Literature Corpus work: ace51739-50ea-5210-99bb-17f8472f17c9
DOI: 10.1101/2024.06.18.24309111

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