Article

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

2023-01-31

Abstract excerpt

Breast cancer metastases exhibit many different genetic alterations, including copy number amplifications. Using publicly available datasets, we identify copy number amplifications in metastatic breast tumor samples and using our organoid-based metastasis assays, and we validate FGFR1 is amplified in collectively migrating organoids. Because the heterogeneity of breast tumors is increasingly becoming relevant to c...

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Literature Corpus work: 11f36ad9-a35b-5bcb-9f52-287c5f537325
DOI: 10.1101/2023.01.29.526141

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