Article

Fluoxetine Modulates Apoptosis and ERK1/2 Phosphorylation in Endometrial Cancer In Vitro

2026-04-22

Abstract excerpt

<title>Abstract</title> <p>Background Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed in oncology settings, yet their direct effects on endometrial cancer cell fate and survival signaling remain unclear. This study examined whether clinically aligned, sub-cytotoxic fluoxetine concentrations modulate viability, cell death phenotype, DNA integrity, and extracellular signal-regulated kinase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11ed771d-6955-5c36-9eb8-3966ec04f0f6
DOI: 10.21203/rs.3.rs-8850312/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fluoxetine Modulates Apoptosis and ERK1/2 Phosphorylation in Endometrial Cancer In VitroDOI 10.21203/rs.3.rs-8850312/v1Read

Antidepressant Sertraline Hydrochloride Inhibits the Growth of HER2+ AU565 Breast Cancer Cell Line through Induction of Apoptosis, and Arrest of Cell CycleSemantic proximity Read

Terpenoids from Zingiber officinale (Ginger) Induce Apoptosis in Endometrial Cancer Cells through the Activation of p53Semantic proximity Read

C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma.Semantic proximity Read

Selective expression of HERG and Kv2 channels influences proliferation of uterine cancer cellsSemantic proximity Read

Fibroblast growth factor receptor inhibition synergizes with Paclitaxel and Doxorubicin in endometrial cancer cells.Semantic proximity Read

Death or survival – progesterone-dependent cell fate decisions in the human endometrial stromaSemantic proximity Read

Efavirenz as a potential drug for the treatment of triple-negative breast cancers.Semantic proximity Read

Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathwaySemantic proximity Read

Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell linesSemantic proximity Read

Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cellsSemantic proximity Read

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicitySemantic proximity Read

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation.Semantic proximity Read