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Article

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity

17 Feb 2009

Abstract excerpt

BACKGROUND: The prototypical antiprogestin mifepristone exhibits potent growth inhibition activity towards ovarian cancer cells in vitro and in vivo. The aim of this research was to establish whether mifepristone is capable of inhibiting cell proliferation and inducing apoptotic cell death regardless of the degree of sensitivity ovarian cancer cells exhibit to cisplatin. METHODS: OV2008, OV2008/C13, A2780,...

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PMID: 19222856
DOI: 10.1186/1475-2867-9-4

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