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Article

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.

Blood - 8 Jan 2015

Chen Edwin, Schneider Rebekka K, Breyfogle Lawrence J, Rosen Emily A, Poveromo Luke, Elf Shannon, Ko Amy, Brumme Kristina, Levine Ross, Ebert Benjamin L, Mullally Ann

Abstract excerpt

Signaling mutations (eg, JAK2V617F) and mutations in genes involved in epigenetic regulation (eg, TET2) are the most common cooccurring classes of mutations in myeloproliferative neoplasms (MPNs). Clinical correlative studies have demonstrated that TET2 mutations are enriched in more advanced phases of MPNs such as myelofibrosis and leukemic transformation, suggesting that they may cooperate with JAK2V617F to...

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Identifiers

PMID: 25281607
DOI: 10.1182/blood-2014-04-567024
PMCID: PMC4287639

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.PMID 25281607Read ↗

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