Article
The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2020
Tiwari Nitija, López-Redondo Marisa, Miguel-Romero Laura, Kulhankova Katarina, Cahill Michael P, Tran Phuong M, Kinney Kyle J, Kilgore Samuel H, Al-Tameemi Hassan, Herfst Christine A, Tuffs Stephen W, Kirby John R, Boyd Jeffery M, McCormick John K, Salgado-Pabón Wilmara, Marina Alberto, Schlievert Patrick M, Fuentes Ernesto J
Abstract excerpt
Staphylococcus aureus infections can lead to diseases that range from localized skin abscess to life-threatening toxic shock syndrome. The SrrAB two-component system (TCS) is a global regulator of S. aureus virulence and critical for survival under environmental conditions such as hypoxic, oxidative, and nitrosative stress found at sites of infection. Despite the critical role of SrrAB in S. aureus pathogenicity,...
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