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A proteomic feasibility study connecting metabolic and synaptic pathway alterations in serum and extracellular vesicles to characterize treatment-resistant depression

2026-08-24

Abstract excerpt

Treatment-resistant depression (TRD) remains a major clinical challenge, yet the biological processes distinguishing TRD from non-treatment-resistant depression (nTRD) are incompletely defined. While circulating serum proteomes reflect broad systemic alterations associated with depression, extracellular vesicles (EVs) could provide a more selective representation of intercellular signaling relevant to treatment re...

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Literature Corpus work
1138c13e-df21-519a-988c-3ea3482a37e0
DOI
10.64898/2026.08.19.745678
Open publication

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