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Epigenetic silencing of HOXA4 gene is associated with imatinib resistance, disease progression, BCR-ABL1 transcript type and smoking status among Chronic Myeloid Leukemia patients

2022-11-18

Abstract excerpt

<title>Abstract</title> <p>Background We aimed to investigate the role of <italic>HOXA4</italic> gene methylation concerning response to imatinib, and chronic myeloid leukemia (CML) progression, also investigated the impact of the type of <italic>BCR-ABL</italic>1 transcript and smoking on methylation level. Methods 45 CML patients at different clinical stages of the disease (including 20 good responses and 25...

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Literature Corpus work
10ff4a68-af98-594e-a6ce-d4bc26f216a5
DOI
10.21203/rs.3.rs-2268696/v1
Open publication

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Epigenetic silencing of HOXA4 gene is associated with imatinib resistance, disease progression, BCR-ABL1 transcript type and smoking status among Chronic Myeloid Leukemia patientsDOI 10.21203/rs.3.rs-2268696/v1
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