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Article

Identification and validation of HOXB3 hypomethylation as a novel prognostically epigenetic biomarker in acute myeloid leukemia.

Frontiers in immunology - 1 Jan 2025

Zhang Ting-Juan, Chang Ran, Xie Fei, Xu Zi-Jun, Chu Ming-Qiang, Wu Xiao-Chi, Qian Jun, Zhou Jing-Dong

Abstract excerpt

Background: Aberrant expression of Homeobox (HOX) genes has been observed in acute myeloid leukemia (AML), but their epigenetic regulatory mechanisms remain largely elusive. Previously, we identified HOXA9 hypomethylation, among HOXA family genes as an epigenetic biomarker for predicting clinical outcomes and guiding treatment choices in AML. Herein, we further investigated the methylation of HOXB family members...

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Topics

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Leukemic

Share to Homeodomain Proteins

Share to Leukemia, Myeloid, Acute

Share to MicroRNAs

Share to Nucleophosmin

Source

Open in PubMed Open full text

Identifiers

PMID: 41601621
DOI: 10.3389/fimmu.2025.1709417
PMCID: PMC12832762

Genes

HOXB3
DNMT3A
FLT3
NPM1
HOXA9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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