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Article

Impact of ABCB1 Gene Polymorphisms and Smoking on the Susceptibility Risk of Chronic Myeloid Leukemia and Cytogenetic Response.

Iranian biomedical journal - 1 Jan 2021

Mohammadi Fatemeh, Shafiei Mohammad, Assad Dlnya, Rostami Golale, Hamid Mohammad, Foroughmand Ali Mohammad

Abstract excerpt

Background: Imatinib mesylate (IM), a strong and selective tyrosine kinase inhibitor, has been approved as the front line of treatment in chronic myeloid leukemia (CML) patients. In spite of satisfactory results of imatinib in the treatment of patients with CML, patients with treatment failure or suboptimal response developed resistance that might be because of pharmacogenetic variants. This study attempted to...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Imatinib Mesylate

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Pharmacogenomic Variants

Share to Smoking

Share to Treatment Failure

Source

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Identifiers

PMID: 33129240
DOI: 10.29252/ibj.25.1.54
PMCID: PMC7748114

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