Article

Characterization of methylation status of the nuclear hormone receptor <i>DAX-1</i> in human cancer

2023-11-22

Abstract excerpt

The orphan receptor DAX-1 plays an essential role in human development, steroid hormone synthesis and the maintenance of embryonic stem cell pluripotency. Recent studies have demonstrated DAX-1 is involved in cancer development, and, depending on the specific cancer type, has a negative or positive effect on cancer growth. In order to better understand the mechanism of DAX-1 gene regulation in various cancer cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10fd9bba-ac0e-5c8d-8c03-e14acc90eb66
DOI: 10.1101/2023.11.21.568180

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of methylation status of the nuclear hormone receptor <i>DAX-1</i> in human cancerDOI 10.1101/2023.11.21.568180Read

DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual DifferentiationSemantic proximity Read

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA.Semantic proximity Read

Mechanisms of Disease: multiple endocrine neoplasia type 1—relation to chromatin modifications and transcription regulationSemantic proximity Read

How Protein Methylation Regulates Steroid Receptor FunctionSemantic proximity Read

Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.Semantic proximity Read

A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita.Semantic proximity Read

The Wilms’ Tumor Suppressor Gene (<i>wt1</i>) Product Regulates <i>Dax-1</i> Gene Expression during Gonadal DifferentiationSemantic proximity Read

Disease-dependent Differently Methylated Regions (D-DMRs) of DNA are Enriched on the X Chromosome in Uterine LeiomyomaSemantic proximity Read

Missense Mutations Cluster within the Carboxyl-Terminal Region of DAX-1 and Impair Transcriptional Repression<sup>1</sup>Semantic proximity Read

Methylation of the Vitamin D Receptor Gene in Human DisordersSemantic proximity Read

DAX1: Increasing complexity in the roles of this novel nuclear receptor.Semantic proximity Read

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.Semantic proximity Read