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Article

A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 1997

Lalli E, Bardoni B, Zazopoulos E, Wurtz J M, Strom T M, Moras D, Sassone-Corsi P

Abstract excerpt

The DAX-1 gene encodes an unusual member of the nuclear hormone receptor superfamily. Mutations in the human DAX-1 gene cause X-linked adrenal hypoplasia congenita associated with hypogonadotropic hypogonadism. We have shown that DAX-1 binds to hairpin secondary structures and blocks steroidogene...

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PMID: 9415399
DOI: 10.1210/mend.11.13.0038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9415399-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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