Article
Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
The Journal of clinical endocrinology and metabolism - 1 Jul 1996
Guo W, Burris T P, Zhang Y H, Huang B L, Mason J, Copeland K C, Kupfer S R, Pagon R A, McCabe E R
Abstract excerpt
The gene responsible for X-linked adrenal hypoplasia congenita, DAX1, encodes a member of the nuclear hormone receptor superfamily. We sequenced 8851 bp that contained the DAX1 genomic region. The DAX gene was composed of two exons and one 3.4-kilobase intron. Putative TATA and GC boxes and a put...
Topics
- Adrenal Insufficiency
- Amino Acid Sequence
- Base Sequence
- DAX-1 Orphan Nuclear Receptor
- DNA-Binding Proteins
- Deoxyribonuclease EcoRI
- Exons
- Female
- Genetic Linkage
- Humans
- Hypogonadism
- Introns
- Male
- Molecular Sequence Data