Article

Chromatographic strategies for the analytical characterization of adeno-associated virus vector-based gene therapy products

2023-05-10

Abstract excerpt

In recent years, the biopharmaceutical industry's interest in gene therapy modalities has increased dramatically. To warrant their quality during manufacturing and upstream/downstream process, fit-for-purpose analytical methods play a crucial role in the overall control strategy. However, characterization of gene therapy products remains challenging due to their large size, structural complexity, heterogeneity, po...

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Literature Corpus work: 10fd3707-9326-50a6-8536-99943b5acb62
DOI: 10.1016/j.trac.2023.117088

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