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Article

Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2016

Dong Tao, He Jing, Wang Shiqing, Wang Lianzhang, Cheng Yuqi, Zhong Yi

Abstract excerpt

The etiology of autism is so complicated because it involves the effects of variants of several hundred risk genes along with the contribution of environmental factors. Therefore, it has been challenging to identify the causal paths that lead to the core autistic symptoms such as social deficit, repetitive behaviors, and behavioral inflexibility. As an alternative approach, extensive efforts have been devoted to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27335463
DOI: 10.1073/pnas.1602152113
PMCID: PMC4941477

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