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Article

Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2020

McDiarmid Troy A, Belmadani Manuel, Liang Joseph, Meili Fabian, Mathews Eleanor A, Mullen Gregory P, Hendi Ardalan, Wong Wan-Rong, Rand James B, Mizumoto Kota, Haas Kurt, Pavlidis Paul, Rankin Catharine H

Abstract excerpt

A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown functional significance. Here, we used Caenorhabditis elegans to systematically functionally characterize ASD-associated genes in vivo. Using our custom machine vision system, we quantified 26 phenotypes spanning morphology, locomotion, tactile sensitivity,...

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Share to Autism Spectrum Disorder
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules, Neuronal

Share to Epistasis, Genetic

Share to Habituation, Psychophysiologic

Share to Immunoglobulins

Share to Locomotion

Share to Phenomics

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Identifiers

PMID: 31754030
DOI: 10.1073/pnas.1912049116
PMCID: PMC6968627

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