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Rapamycin-PLGA microspheres induce autophagy and prevent senescence in chondrocytes and exhibit long <i>in vivo</i> residence

2020-04-06

Abstract excerpt

Osteoarthritis (OA) is a joint disease that results in progressive destruction of articular cartilage and the adjoining subchondral bone. The current treatment is focused on symptomatic relief due to the absence of disease-modifying drugs. The primary cells of the cartilage, chondrocytes, have limited regenerative capacity and when they undergo stress due to trauma or with aging, they senesce or become apoptotic....

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Literature Corpus work
10d3dbe2-a729-5c2a-b9d3-6361b14e3f1e
DOI
10.1101/2020.04.06.027136
Open publication

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Rapamycin-PLGA microspheres induce autophagy and prevent senescence in chondrocytes and exhibit long <i>in vivo</i> residenceDOI 10.1101/2020.04.06.027136
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