Article

Methylcellulose in culture medium regulates size, cell viability, cytokine production, and exosome secretion in adipose-derived stem cell spheroids cultured using SphereRing® system

2025-09-05

Abstract excerpt

Knee osteoarthritis (OA) is a degenerative disease that impairs joint function. Adipose-derived stem cells (ADSCs) are promising for therapy due to their regenerative potential, particularly when cultured as spheroids to enhance paracrine activity. However, conventional plate-based spheroid culture faces challenges such as scalability limits, retrieval difficulties, excessive enlargement, and necrotic core formati...

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Literature Corpus work: 8da60376-07f5-5b04-b8c5-0f6382a06e45
DOI: 10.1016/j.bej.2025.109929

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