Article

Single step, high efficiency CRISPR-Cas9 genome editing in primary human disease-derived fibroblasts

2018-10-11

Abstract excerpt

Genome editing is a tool that has many applications including the validation of potential drug targets. However, performing genome editing in low passage, primary human cells with the greatest physiological relevance, is notoriously difficult. High editing efficiency is desired because it enables gene knock outs (KO) to be generated in bulk cellular populations and circumvents the problem of having to generate clo...

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Identifiers and source

Literature Corpus work: 10a6df66-48e3-52aa-9c0c-ebfda62cda67
DOI: 10.1101/440099

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