Article

Measurement of selective constraint on human gene expression

2018-06-13

Abstract excerpt

Gene expression variation is a major contributor to phenotypic variation in human complex traits. Selection on complex traits may therefore be reflected in constraint on gene expression levels. Here, we explore the effects of stabilizing selection on cis -regulatory genetic variation in humans. We analyze patterns of expression variation at copy number variants and find evidence for selection against large increa...

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Literature Corpus work: 10a08049-1c45-5cf6-ac07-7b52eb472a8c
DOI: 10.1101/345801

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