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Light and sex modify <i>Snord116</i> genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment

2025-05-07

Abstract excerpt

<h4>Summary</h4> Mammals utilize imprinted and X-linked epigenetic mechanisms in development, metabolism, and behavior. Imprinted genes, including Prader-Willi syndrome Snord116 noncoding RNAs, are implicated in the regulation of sleep and circadian rhythms through poorly understood mechanisms. Utilizing mouse models of Snord116 deficiency and overexpression, we performed an integrated, sex-stratified analysis...

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Literature Corpus work
03af7e99-2e08-567f-8576-d95cd32f30d7
DOI
10.1101/2025.05.01.651733
Open publication

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Light and sex modify <i>Snord116</i> genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainmentDOI 10.1101/2025.05.01.651733
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