Article

The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization

2019-09-25

Abstract excerpt

Whole-genome expression data generated by microarray studies have shown promise for quantitative human health risk assessment. While numerous approaches have been developed to determine benchmark doses (BMDs) from probeset-level dose responses, sensitivity of the results to methods used for normalization of the data has not yet been systematically investigated. Normalization of microarray data converts raw hybridi...

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Literature Corpus work: 104345ac-861a-538b-910d-0b8a6a6e0da2
DOI: 10.1101/781567

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