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Article

Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for Glaucoma

16 Jan 2009

Abstract excerpt

BACKGROUND: Glaucoma is the world's second leading cause of bilateral blindness with progressive loss of vision due to retinal ganglion cell death. Myocilin has been associated with congenital glaucoma and 2-4% of primary open angle glaucoma (POAG) cases, but the pathogenic mechanisms remain largely unknown. Among several hypotheses, activation of the unfolded protein response (UPR) has emerged as a possible...

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PMID: 19148291
DOI: 10.1371/journal.pone.0004216

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Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for GlaucomaPMID 19148291Read ↗

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