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Article

Small p53 derived peptide suitable for robust nanobodies dimerization.

Journal of immunological methods - 1 Nov 2021

Dietsch Frank, Nominé Yves, Stoessel Audrey, Kostmann Camille, Bonhoure Anna, Chatton Bruno, Donzeau Mariel

Abstract excerpt

Bivalent VHHs have been shown to display better functional affinity compared with their monovalent counterparts. Bivalency can be achieved either by inserting a hinge region between both VHHs units or by using modules that lead to dimerization. In this report, a small self-associating peptide originating from the tetramerization domain of p53 was developed as a tool for devicing nanobody dimerization. This E3...

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PMID: 34481824
DOI: 10.1016/j.jim.2021.113144

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