Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OrthoDisease: tracking disease gene orthologs across 100 species.

Briefings in bioinformatics - 1 Sept 2011

Forslund Kristoffer, Schreiber Fabian, Thanintorn Nattaphon, Sonnhammer Erik L L

Abstract excerpt

Orthology is one of the most important tools available to modern biology, as it allows making inferences from easily studied model systems to much less tractable systems of interest, such as ourselves. This becomes important not least in the study of genetic diseases. We here review work on the orthology of disease-associated genes and also present an updated version of the InParanoid-based disease orthology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome
Share to Phylogeny
Share to Software

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Disease

Share to Disease Models, Animal

Share to Genetic Predisposition to Disease

Share to Species Specificity

Source

Identifiers

PMID: 21565935
DOI: 10.1093/bib/bbr024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OrthoDisease: tracking disease gene orthologs across 100 species.PMID 21565935Read ↗

OrthoDB: a hierarchical catalog of animal, fungal and bacterial orthologs.Semantic proximity Read ↗

On the origins of Mendelian disease genes in man: the impact of gene duplication.Semantic proximity Read ↗

Evolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animalsSemantic proximity Read ↗

The landscape of gene loss and missense variation across the mammalian tree informs on gene essentialitySemantic proximity Read ↗

Applications of comparative evolution to human disease genetics.Semantic proximity Read ↗

Human genetic disease is greatly influenced by the underlying fragility of evolutionarily ancient genesSemantic proximity Read ↗

Phylogenetic Identification and Functional Characterization of Orthologs and Paralogs across Human, Mouse, Fly, and WormSemantic proximity Read ↗

Loss of critical developmental and human disease-causing genes in 58 mammalsSemantic proximity Read ↗

Differences in the evolutionary history of disease genes affected by dominant or recessive mutations.Semantic proximity Read ↗

Gene duplication: a drive for phenotypic diversity and cause of human disease.Semantic proximity Read ↗

An integrative approach to ortholog prediction for disease-focused and other functional studies.Semantic proximity Read ↗

Gephebase, a Database of Genotype-Phenotype Relationships for natural and domesticated variation in EukaryotesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.