Article

Accelerating Complex Genomic Design Tasks: AI-Guided gRNA Optimization for <em>TP53 </em>with GeneForgeLang

2025-09-02

Abstract excerpt

The CRISPR-Cas9 system has revolutionized genome engineering, but its clinical and research success hinges on the design of highly efficient and specific guide RNAs (gRNAs). This design process presents a complex multi-objective optimization challenge. Current computational approaches often rely on single-pass prediction models or require researchers to build bespoke, difficult-to-maintain scripting pipelines for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fd91591-fc27-5caa-a5ea-4e24e3a1c932
DOI: 10.20944/preprints202509.0193.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Accelerating Complex Genomic Design Tasks: AI-Guided gRNA Optimization for <em>TP53 </em>with GeneForgeLangDOI 10.20944/preprints202509.0193.v1Read

CRISPR-GPT for Agentic Automation of Gene Editing ExperimentsSemantic proximity Read

Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequencesSemantic proximity Read

Machine learning methods for predicting guide RNA effects in CRISPR epigenome editing experimentsSemantic proximity Read

Transitioning from Wet Lab to Artificial Intelligence: A Systematic Review of AI predictors in CRISPRSemantic proximity Read

OPED: an optimal prime editing guide RNA designer based on deep learning and transfer learningSemantic proximity Read

Efficient exploration of sequence space enables rapid generation of functional genome editorsSemantic proximity Read

Capturing Natural Evolution in Function-guided RNA Design via Genomic Foundation ModelsSemantic proximity Read

From Code to Cure: How Generative AI Is Reinventing Drug DiscoverySemantic proximity Read

A high-level programming language for generative biology with ProtoSemantic proximity Read

Deep learning-guided engineering of SpuFz1 and rational miniaturization of ωRNA enables efficient genome editing.Semantic proximity Read

EternaBrain: Automated RNA design through move sets and strategies from an Internet-scale RNA videogameSemantic proximity Read

Pipette: Encoding scientific literature into an executable Skill Graph for multi-agent bioinformaticsSemantic proximity Read