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The regulatory architecture of gene expression variation in Caenorhabditis elegans revealed by multi-strain allele-specific analysis.

Genetics - 6 Aug 2025

Bell Avery Davis, Valencia Francisco, Paaby Annalise B

Abstract excerpt

An outstanding question in the evolution of gene expression is the composition of the underlying regulatory architecture and the processes that shape it. Mutations affecting a gene's expression may reside locally in cis or distally in trans; the accumulation of these changes, their interactions, and their modes of inheritance influence how traits are expressed and how they evolve. Here, we interrogated gene...

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PMID: 40492337
DOI: 10.1093/genetics/iyaf110
PMCID: PMC12529284

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