Article

Distal-less homeobox 5 gives rise to myofibroblastic carcinoma-associated fibroblasts to promote collective breast cancer invasion

2026-08-31

Abstract excerpt

Tumor-promoting myofibroblastic carcinoma-associated fibroblasts (myCAFs) are induced by activation of transforming growth factor-β signaling. However, the molecular basis of myCAF-specific transcriptional programs regulated by TGF-β signaling remains poorly understood. Using a meta-analysis of single-cell RNA-seq data from 132 human breast tumor and non-tumor tissues, we show that myCAFs activate gene regulatory...

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Literature Corpus work: 0fb67e14-3b99-56f0-838d-3155ffabdad7
DOI: 10.64898/2026.08.30.745418

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Distal-less homeobox 5 gives rise to myofibroblastic carcinoma-associated fibroblasts to promote collective breast cancer invasionDOI 10.64898/2026.08.30.745418Read

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