Article

Study of effect modifiers of genetically predicted CETP reduction

2021-10-12

Abstract excerpt

<title>Abstract</title> <p>Genetic variants in drug targets can be used to predict the effect of drugs. Here, we extend this principle to assess how sex and body mass index may modify the effect of a genetically predicted lower CETP levels on biomarkers and cardiovascular outcomes. We found sex and BMI to be modifiers of the association between genetically predicted lower CETP and lipid biomarkers in UK Biobank p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fa586d9-84a0-5bc5-8987-c0b73bb09552
DOI: 10.21203/rs.3.rs-930142/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Study of effect modifiers of genetically predicted CETP reductionDOI 10.21203/rs.3.rs-930142/v1Read

Study of effect modifiers of genetically predicted CETP reductionSemantic proximity Read

Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomizationSemantic proximity Read

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisationSemantic proximity Read

A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass IndexSemantic proximity Read

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisationSemantic proximity Read

Cholesteryl Ester Transfer Protein as a Drug Target for Cardiovascular DiseaseSemantic proximity Read

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human geneticsSemantic proximity Read

Pleiotropic effects of statins on ischemic heart disease: a Mendelian Randomization study in the UK BiobankSemantic proximity Read

Causal effects of lipid-lowering therapies on aging-related outcomes and risk of cancers: a drug-target Mendelian randomization study.Semantic proximity Read

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.Semantic proximity Read

CETP inhibition Reduces Cardiovascular Events by Lowering of Cumulative LDL Exposure: Reconciling Evidence from Human Genetics and Clinical TrialsSemantic proximity Read

CETP alternative splicing variation impacts human traitsSemantic proximity Read