Article

Loss of glia-neuronal interactions and age-dependent cell death in a <i>Drosophila</i> model of adult neurodegeneration

2024-05-20

Abstract excerpt

While glial dysfunction has been implicated in the development of multiple neurodegenerative diseases, the role of glial cell morphology in neurodegeneration is underexplored. In the fruit fly Drosophila melanogaster , mutants of the gene drop-dead ( drd ) exhibit adult neurodegeneration and extremely short lifespans. The morphology of one class of glia, the cortex glia (CG), is abnormal in drd mutants. In con...

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Literature Corpus work: 0f7b69c2-6efe-5f9d-a534-784928007d54
DOI: 10.1101/2024.05.20.595004

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