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Article

Unexpected molecular mechanism of Orc6-based Meier-Gorlin syndrome: insights from a humanized Drosophila model.

Genetics - 12 Nov 2025

Balasov Maxim, Akhmetova Katarina, Chesnokov Igor

Abstract excerpt

Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterized by microtia, primordial dwarfism, and skeletal abnormalities. Patients with MGS often carry mutations in genes encoding the subunits of the origin recognition complex (ORC), components of the prereplicative complex and replication machinery. ORC6, an essential ORC subunit, plays a critical role in both DNA replication and...

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Identifiers

PMID: 40986665
DOI: 10.1093/genetics/iyaf203
PMCID: PMC12606431

Genes

ORC6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Unexpected molecular mechanism of Orc6-based Meier-Gorlin syndrome: insights from a humanized Drosophila model.PMID 40986665Read ↗

Unexpected Molecular Mechanism of Orc6-Based Meier-Gorlin Syndrome: Insights from a Humanized Drosophila ModelSemantic proximity Read ↗

Humanized Drosophila Model of the Meier-Gorlin Syndrome Reveals Conserved and Divergent Features of the Orc6 Protein.Semantic proximity Read ↗

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Humanized <i>Drosophila</i> model of the Meier-Gorlin syndrome reveals conserved and divergent features of the Orc6 proteinSemantic proximity Read ↗

Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4.Semantic proximity Read ↗

A Meier-Gorlin Syndrome Mutation in Orc4 Causes Tissue-Specific DNA Replication Defects in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

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Meier-Gorlin Syndrome: Clinical Misdiagnosis, Genetic Testing and Functional Analysis of ORC6 Mutations and the Development of a Prenatal Test.Semantic proximity Read ↗

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