Article

Fusion detection and quantification by pseudoalignment

2017-07-20

Abstract excerpt

RNA sequencing in cancer cells is a powerful technique to detect chromosomal rearrangements, allowing for de novo discovery of actively expressed fusion genes. Here we focus on the problem of detecting gene fusions from raw sequencing data, assembling the reads to define fusion transcripts and their associated breakpoints, and quantifying their abundances. Building on the pseudoalignment idea that simplifies and...

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Literature Corpus work: 0f5be956-1e7e-5c7e-90e0-0d2e9109147e
DOI: 10.1101/166322

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