Article

Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles

2025-07-02

Abstract excerpt

Skeletal muscles and blood vessels are continuously exposed to mechanical forces, particularly during exercise. We subjected human endothelial and skeletal muscle cells to cyclic mechanical stretch to mimic exercise and investigated acute molecular responses. Mechanical loading elicited both shared and cell type-specific alterations in transcriptomic and metabolomic profiles, several of which mirrored changes obse...

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Literature Corpus work: 0f3a942e-3a4a-55eb-905c-c3710dcd54e9
DOI: 10.1101/2025.06.27.661962

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