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Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology

28 Sept 2022

Abstract excerpt

Abstract Resistance to programmed cell death (PCD) is a hallmark of cancer. While some PCD components are prognostic in cancer, the roles of many molecules can be masked by redundancies and crosstalks between PCD pathways, impeding the development of targeted therapeutics. Recent studies characterizing these redundancies have identified PANoptosis, a unique innate immune-mediated inflammatory PCD pathway that...

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PMID: 36329783
DOI: 10.1093/narcan/zcac033

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