Article

The Effect of Population Structure on Murine Genome-Wide Association Studies

2020-09-03

Abstract excerpt

Population structure (PS) has been shown to cause false positive signals in genome-wide association studies (GWAS). Since PS correction is routinely used in human GWAS, it was assumed that it also should be utilized for murine GWAS using inbred strains. Nevertheless, there are fundamental differences between murine and human GWAS, and the impact of PS on murine GWAS results has not been thoroughly investigated. To...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f2184ac-092c-5ace-82a3-9bc637b7a53b
DOI: 10.1101/2020.09.01.278762

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Effect of Population Structure on Murine Genome-Wide Association StudiesDOI 10.1101/2020.09.01.278762Read

Efficient control of population structure in model organism association mapping.Semantic proximity Read

Review: Population Structure in Genetic Studies: Confounding Factors and Mixed ModelsSemantic proximity Read

Prospects for association mapping in classical inbred mouse strains.Semantic proximity Read

High Throughput Computational Mouse Genetic AnalysisSemantic proximity Read

Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Semantic proximity Read

Genome-wide association studies in mice.Semantic proximity Read

A better prognosis for genetic association studies in mice.Semantic proximity Read

Fine mapping in 94 inbred mouse strains using a high-density haplotype resource.Semantic proximity Read

Analysis of Inbred Mouse strains’ High-Impact Genotype-phenotype Hypotheses (AIMHIGH) reveals novel disease-causing candidate genesSemantic proximity Read

Computational genetics: from mouse to human?Semantic proximity Read

Data-driven prioritization of mouse strains for improved preclinical modeling of rare and common diseaseSemantic proximity Read

Local ancestry corrects for population structure in Saccharomyces cerevisiae genome-wide association studies.Semantic proximity Read