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Article

Zika virus crosses an in vitro human blood brain barrier model

10 May 2018

Abstract excerpt

Zika virus (ZIKV) is a flavivirus that is highly neurotropic causing congenital abnormalities and neurological damage to the central nervous systems (CNS). In this study, we used a human induced pluripotent stem cell (iPSC)-derived blood brain barrier (BBB) model to demonstrate that ZIKV can infect brain endothelial cells (i-BECs) without compromising the BBB barrier integrity or permeability. Although no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29759080
DOI: 10.1186/s12987-018-0100-y

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