Article

Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine

2025-11-08

Abstract excerpt

Gonorrhea is increasingly resistant to treatment and has been labelled an urgent threat due to the diminishing effectiveness of existing therapeutics. To address this challenge, we targeted the Neisseria gonorrhoeae transferrin binding protein B (TbpB), which is critical for iron acquisition and neisserial growth, as a vaccine target. Building on previous studies investigating the application of TbpB as an immuno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7dc408bb-b42c-58a3-a107-1dd85ef17443
DOI: 10.1101/2025.11.06.685839

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccineDOI 10.1101/2025.11.06.685839Read

Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against <i>Neisseria gonorrhoeae</i>Semantic proximity Read

Rationally designed minimized TbpB confers broad protection against meningococcal infectionSemantic proximity Read

The transferrin–iron import system from pathogenic N eisseria speciesSemantic proximity Read

Point Mutations in TbpA Abrogate Human Transferrin Binding in Neisseria gonorrhoeaeSemantic proximity Read

Structural Basis for Evasion of Nutritional Immunity by the Pathogenic NeisseriaeSemantic proximity Read

Antigenic and Sequence Diversity in Gonococcal Transferrin-Binding Protein ASemantic proximity Read

TonB-Dependent Transporters Expressed by Neisseria gonorrhoeaeSemantic proximity Read

Proteomics, Bioinformatics and Structure-Function Antigen Mining For Gonorrhea VaccinesSemantic proximity Read

Investigating the importance of selected surface-exposed loops in HpuB for hemoglobin binding and utilization by Neisseria gonorrhoeae.Semantic proximity Read

Rational design of a meningococcal antigen inducing broad protective immunity.Semantic proximity Read

Preclinical Evaluation of Novel Conserved <em>Neisseria gonorrhoeae</em> Vaccine Candidates Identified Through Infection-Informed Antigen DiscoverySemantic proximity Read

Proteomics-driven Antigen Discovery for Development of Vaccines Against GonorrheaSemantic proximity Read