Back to search

Article

High-throughput proteomics identifies THEMIS2 as independent biomarker of treatment-free survival in untreated CLL

2022-12-07

Abstract excerpt

<title>Abstract</title> <p>It remains challenging in chronic lymphocytic leukemia (CLL) to distinguish between patients with favorable and unfavorable time to first treatment (TTFT). Additionally, the downstream protein correlates of well-known molecular features of CLL are not always clear. To address this, we selected 40 CLL patients with TTFT ≤ 24 months and compared their B cell intracellular protein expressi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0ebf18f1-37eb-5c2e-bb1b-0e31f94c2d31
DOI
10.21203/rs.3.rs-2312822/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
High-throughput proteomics identifies THEMIS2 as independent biomarker of treatment-free survival in untreated CLLDOI 10.21203/rs.3.rs-2312822/v1
Proteomic profiling based classification of CLL provides prognostication for modern therapy and identifies novel therapeutic targets.Semantic proximity
Proteogenomics refines the molecular classification of chronic lymphocytic leukemiaSemantic proximity
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.Semantic proximity
Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome DysregulationSemantic proximity
The protein landscape of chronic lymphocytic leukemia.Semantic proximity
Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.Semantic proximity
Proteome landscape of B-cell malignancies identifies mantle cell lymphoma protein signatureSemantic proximity
RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences.Semantic proximity
Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy: results from the HOVON 109 study.Semantic proximity
Integrated Proteomic and Network Analysis Reveals Dysregulated Pathways and Candidate Proteins in Multiple Myeloma ProgressionSemantic proximity
Multipronged functional proteomics approaches for global identification of altered cell signalling pathways in B-cell chronic lymphocytic leukaemia.Semantic proximity
Analysis of chronic lymphotic leukemia transcriptomic profile: differences between molecular subgroups.Semantic proximity
Select a neighboring publication to make it the new centre.