Article
Multipronged functional proteomics approaches for global identification of altered cell signalling pathways in B-cell chronic lymphocytic leukaemia.
Proteomics - 1 Apr 2016
Díez Paula, Lorenzo Seila, Dégano Rosa M, Ibarrola Nieves, González-González María, Nieto Wendy, Almeida Julia, González Marcos, Orfao Alberto, Fuentes Manuel
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) is a malignant B cell disorder characterized by its high heterogeneity. Although genomic alterations have been broadly reported, protein studies are still in their early stages. Herein, a 224-antibody microarray has been employed to study the intracellular signalling pathways in a cohort of 14 newly diagnosed B-CLL patients as a preliminary study for further investigations....
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