Article
Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.
Molecular & cellular proteomics : MCP - 1 Apr 2015
Eagle Gina L, Zhuang Jianguo, Jenkins Rosalind E, Till Kathleen J, Jithesh Puthen V, Lin Ke, Johnson Gillian G, Oates Melanie, Park Kevin, Kitteringham Neil R, Pettitt Andrew R
Abstract excerpt
The mutational status of the immunoglobulin heavy chain variable region defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and unmutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with UM-CLL, total proteomes from nine UM-CLL and nine M-CLL samples were analyzed by isobaric tags for relative and absolute...
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