Article

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

2022-12-11

Abstract excerpt

While the introduction of immune checkpoint blockade (ICB) has dramatically improved clinical outcomes for patients with advanced melanoma, a significant proportion of patients develop resistance to therapy, and mechanisms of resistance are poorly elucidated in most cases. Further, while combination ICB has higher response rates and improved progression free survival compared to single agent therapy in the front l...

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Literature Corpus work: 0eb541f7-b585-5cbf-a695-aee4b5e569c4
DOI: 10.1101/2022.12.11.519808

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