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Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade

2 Mar 2023

Abstract excerpt

Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterization using mouse melanoma models, we show that the KEAP1/NRF2 pathway modulates sensitivity to ICB, independently of tumorigenesis. The NRF2 negative regulator, KEAP1, shows...

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PMID: 36864091
DOI: 10.1038/s41698-023-00362-3

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