Article

RNA-sequencing reveals strong predominance of <i>THRA</i> splicing isoform 2 in the developing and adult human brain

2023-12-22

Abstract excerpt

Thyroid hormone receptor alpha (THR α ) is a nuclear hormone receptor that binds triiodothyronine (T3) and acts as an important transcription factor in development, metabolism and reproduction. THR α has in mammals two major splicing isoforms, THR α 1 and THR α 2. The better characterized isoform, THR α 1, is a transcriptional stimulator of genes involved in cell metabolism and growth. The less well character...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0eab7cdb-21f3-5926-be34-4e58d6ea8523
DOI: 10.1101/2023.12.22.573013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA-sequencing reveals strong predominance of <i>THRA</i> splicing isoform 2 in the developing and adult human brainDOI 10.1101/2023.12.22.573013Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanismsSemantic proximity Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.Semantic proximity Read

Bichromatic Splicing Detector Allows Quantification of THRA1 and THRA2 Splicing Isoforms in Single Cells by Fluorescent Live-Cell ImagingSemantic proximity Read

Expansion of RNA sequence diversity and RNA editing rates throughout human cortical developmentSemantic proximity Read

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortexSemantic proximity Read

The conserved landscape of RNA modifications and transcript diversity across mammalian evolutionSemantic proximity Read

An atlas of expressed transcripts in the prenatal and postnatal human cortexSemantic proximity Read

Data-driven Identification of Total RNA Expression Genes (TREGs) for Estimation of RNA Abundance in Heterogeneous Cell TypesSemantic proximity Read

Divergent landscapes of A-to-I editing in postmortem and living human brainSemantic proximity Read

Cross-tissue isoform switches by human transcription factors suggest a widespread regulatory mechanismSemantic proximity Read

Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathologySemantic proximity Read

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriersSemantic proximity Read