Article

<i>In Silico</i> Network Perturbation Reveals Hierarchical Roles of DNA Repair and Glycosylation Linking Exercise to Human Ageing Clocks

2026-02-03

Abstract excerpt

Regular physical activity delays biological ageing, yet how transient exercise-induced molecular responses are translated into stable ageing signatures in humans remains unclear. Here, we introduce the first in silico perturbation framework for human exercise biology that integrates genetically anchored gene prioritisation, graph-based network modelling, and human experimental validation. Genes causally associate...

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Literature Corpus work: 383d1c18-c1e1-5ac5-90fd-c617980c07b1
DOI: 10.64898/2026.02.01.26345311

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