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Article

Replicated blood-based biomarkers for myalgic encephalomyelitis not explicable by inactivity

19 Jun 2025

Abstract excerpt

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common female-biased disease. ME/CFS diagnosis is hindered by the absence of biomarkers that are unaffected by patients' low physical activity level. Our analysis used semi-parametric efficient estimators, an initial Super Learner fit followed by a one-step correction, three mediators, and natural direct and indirect estimands, to decompose the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40537675
DOI: 10.1038/s44321-025-00258-8

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