Article
Integration of multiomic and multi-phenotypic data identifies biological pathways associated with physical fitness.
Communications biology - 17 Feb 2026
Alizadeh Azar, Graf John, Misner Matthew J, Burns Andrew A, Ginty Fiona, O'Donovan Kevin J, Wickiser J Kenneth, Barringer Nicholas, Freisinger Gregory, Hermansen Neil Herm, McDonough J Elizabeth, Davis Brian, Loghin Evelina R, Surrette Christine, Tu Peter, Welch Justin, Boomhower Oliver, Lenigk Ralf, Sorrell Rachel, Hammond Tyler, Peterson Sara, Caron Alison, Safazadeh Leila, Chadwick Chrystal, Stacey Stephanie, Jobin James, Evans Scott C, Xu Rui, Khinda Gurvinder S, Williams Eric D, Chhabra Swapnil, Huynh Nhan, Joseph Taisha, Fraenkel Ernest, Marinelli Luca
Abstract excerpt
Unraveling the complex associations between human phenotypes and molecular pathways can pave the way to improved health and performance, but faces a fundamental challenge: the measurable genes, proteins, and metabolites vastly outnumber the participants in even the largest studies, yielding spurious correlations. To address this, we developed PhenoMol, a bioinformatic framework that integrates comprehensive...
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