Article

Complex structural variation, phylogeny, and disease associations of the mucin pangenome

2026-07-04

Abstract excerpt

Mucins are large glycoproteins that provide hydration and barrier function to epithelial tissues. Although genetically heterogeneous, all mucins harbor a large exon composed of variable number tandem repeats (VNTRs). Short-read sequencing has limited our understanding of mucin VNTR diversity and makes disease association studies challenging. We leverage 296 long-read phased genome assemblies to characterize 14 muc...

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Literature Corpus work: 33625209-d158-5f49-b483-dc02f5a93e13
DOI: 10.64898/2026.07.01.26356476

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